August 19, 2007
Psychiatrie : des experts trop liés à l'industrie
Experts Defining Mental Disorders Are Linked to Drug Firms
Washington Post Staff Writer
Thursday, April 20, 2006; Page A07
Every psychiatric expert involved in writing the standard diagnostic criteria for disorders such as depression and schizophrenia has had financial ties to drug companies that sell medications for those illnesses, a new analysis has found.
Of the 170 experts in all who contributed to the manual that defines disorders from personality problems to drug addiction, more than half had such ties, including 100 percent of the experts who served on work groups on mood disorders and psychotic disorders. The analysis did not reveal the extent of their relationships with industry or whether those ties preceded or followed their work on the manual.
"I don't think the public is aware of how egregious the financial ties are in the field of psychiatry," said Lisa Cosgrove, a clinical psychologist at the University of Massachusetts in Boston, who is publishing her analysis today in the peer-reviewed journal Psychotherapy and Psychosomatics.
The analysis comes at a time of growing debate over the rising use of medication as the primary or sole treatment for many psychiatric disorders, a trend driven in part by definitions of mental disorders in the psychiatric manual.
Cosgrove said she began her research after discovering that five of six panel members studying whether certain premenstrual problems are a psychiatric disorder had ties to Eli Lilly & Co., which was seeking to market its drug Prozac to treat those symptoms. The process of defining such disorders is far from scientific, Cosgrove added: "You would be dismayed at how political the process can be."
The American Psychiatric Association, which publishes the guidelines in its bible of disorders, the Diagnostic and Statistical Manual (DSM), said it is planning to require disclosure of the financial ties of experts who write the next edition of the manual -- due around 2011. The manual carries vast influence over the practice of psychiatry in the United States and around the world.
Darrel Regier, director of the association's division of research, said that concerns over disclosure are a relatively recent phenomenon, which may be why the last edition, published in 1994, did not note them. Regier and John Kane, an expert on schizophrenia who worked on the last edition, agreed with the need for transparency but said financial ties with industry should not undermine public confidence in the conclusions of its experts. Kane has been a consultant to drug companies including Abbott Laboratories, Eli Lilly, Janssen and Pfizer Inc.
"It shouldn't be assumed there is a true conflict of interest," said Kane, who said his panel's conclusions were driven only by science. "To me, a conflict of interest implies that someone's judgment is going to be influenced by this relationship, and that is not necessarily the case. . . ."
The DSM defines disorders in terms of constellations of symptoms. While neuroscience and genetics are revealing biological aspects to many disorders, there has been unease that psychiatry is ignoring social, psychological and cultural factors in its pursuit of biological explanations and treatments.
"As a profession, we have allowed the biopsychosocial model to become the bio-bio-bio model," Steven Sharfstein, president of the American Psychiatric Association, said in an essay last year to his colleagues. He later added, "If we are seen as mere pill pushers and employees of the pharmaceutical industry, our credibility as a profession is compromised."
He stressed that the association has strict guidelines to police the role of the pharmaceutical industry but said the profession as a whole needs to do a better job monitoring ethical conflicts.
Sharfstein added yesterday that the presence of experts with ties to companies on the manual's expert panels is understandable, given that many of the top experts in the field are involved in drug research.
"I am not surprised that the key people who participate have these kinds of relationships," he said. "They are the major researchers in the field, and are very much on the cutting edge, and will have some kind of relationship -- but there should be full disclosure."
At least one psychiatrist who worked on the current manual criticized the analysis. Nancy Andreasen of the University of Iowa, who headed the schizophrenia team, called the new analysis "very flawed" because it did not distinguish researchers who had ties to industry while serving on the panel from those who formed such ties afterward.
Two out of five researchers on her team had had substantial ties to industry, she said. Andreasen said she would have to check her tax statements to know whether she received money from companies at the time she worked on the panel, but said, "What I do know is that I do almost nothing with drug companies. . . . My area of research is neuroimaging, not psychopharmacology."
The analysis could not determine the extent or timing of the financial ties because it relied on disclosures in journal publications and other venues that do not mention many details, said Sheldon Krimsky, a science policy specialist at Tufts University who also was an author of the new study. Whether the researchers received money before, during or after their service on the panel did not remove the ethical concern, he said.
Krimsky, the author of the book "Science in the Private Interest," added that although more transparency is welcome, the psychiatric association should staff its panels with disinterested experts.
"When someone is establishing a clinical guideline for the bible of psychiatric diagnosis, I would argue they should have no affiliation with the drug companies in those areas where the companies could benefit from those decisions," he said.
Study Finds a Link of Drug Makers to Psychiatrists NY Times, published: April 20, 2006 More than half the psychiatrists who took part in developing a widely used diagnostic manual for mental disorders had financial ties to drug companies before or after the manual was published, public health researchers reported yesterday. The researchers found that 95 — or 56 percent — of 170 experts who worked on the 1994 edition of the manual, called the Diagnostic and Statistical Manual, or D.S.M, had at least one monetary relationship with a drug maker in the years from 1989 to 2004. The most frequent tie involved money for research, according to the study, an analysis of financial records and conflict-of-interest statements. The percentage was higher — 100 percent in some cases — for experts who worked on sections of the manual devoted to severe mental illnesses, like schizophrenia, the study found. But the authors, from Tufts University and the University of Massachusetts, were not able to establish how many of the psychiatrists were receiving money from drug companies while the manual was being compiled. Lisa Cosgrove, the study's lead author, who is a psychologist at the University of Massachusetts in Boston, said that although the study could not prove that the psychiatrists' ties influenced the manual's development, "what we're saying is it's outrageous that the manual doesn't have a disclosure policy." But other experts scoffed at the idea that commercial interests had influenced either the language or content of the manual. "I can categorically say, and I was there every step of the way, that drug-company influence never entered into any of the discussions, whatsoever," said Dr. Michael First, a psychiatry professor at Columbia, who coordinated development of the current D.S.M. Some 400,000 mental health workers, from psychiatrists to nurses, use the manual to diagnose disorders in patients, and health insurers use the manual to determine coverage. In recent years, critics have said that the manual has become too expansive, including diagnoses, like social phobia, that they say appear tailor-made to create a market for antidepressants or other drugs. The study investigated the financial ties by sifting through legal files, patent records, conflict-of-interest databases and journal articles, among other records. Twenty-two percent of the experts received consulting income in the years from 1989 to 2004, the study found, and 16 percent served as members of a drug maker's speakers bureau. Such services are typically more lucrative than research support. |
Posted 18 years, 1 month ago on August 19, 2007
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PsychoMédia(.qc.ca) - Publié le 20 avril 2006, extrait
Tous les psychiatres experts impliqués dans l'écriture des critères pour des troubles comme la dépression et la schizophrénie ont des liens financiers avec les compagnies pharmaceutiques qui vendent des médicaments pour ces maladies, selon une nouvelle analyse.
Des 170 experts qui ont contribué au manuel qui définit les troubles mentaux (le DSM IV : The Diagnostic and Statistical Manual of Mental Disorders) qui vont des troubles de la personnalité à la dépendance aux drogues, plus de la moitié avaient de tels liens, incluant 100% des experts qui ont participé aux groupes de travail sur les troubles de l'humeur et les troubles psychotiques.
L'analyse ne révèle cependant pas pas l'étendue de leurs relations avec l'industrie ou si ces liens ont précédé ou suivi leur travail sur le manuel.
"Je ne pense pas que le public soit conscient que les liens financiers soient si importants dans le champs de la psychiatrie" dit Lisa Cosgrove, psychologue clinicienne à l'Université du Massachusetts à Boston, qui a publié cette analyse dans le journal Psychotherapy and Psychosomatics.
Psychiatrie : des experts trop liés à l'industrie
Le Figaro, 24 avril 2006, extrait
Rubrique Sciences & Médecine
La majorité des auteurs du principal manuel de diagnostic des maladies mentales sont liés financièrement à l'industrie pharmaceutique.
LE SOUPÇON circulait depuis vingt ans dans le milieu psychiatrique. Mais la preuve vient d'en être administrée par une chercheuse américaine : la moitié des experts psychiatres qui ont participé à la rédaction du plus célèbre manuel de classification diagnostique des maladies mentales (le DSM4 *) sont payés par l'industrie pharmaceutique, qui fabrique justement les médicaments utiles dans ces maladies. Lisa Cosgrove, chercheuse à l'université du Massachusetts de Boston, a publié le 21 avril, dans la revue Psycho-therapy and Psychosomatics, le résultat d'une enquête très fouillée sur les liens des experts avec l'industrie : sur les 170 membres des groupes de travail ayant participé à l'élaboration de ce manuel, 95 (soit 56%) ont une ou plusieurs attaches financières avec des firmes. Une enquête révélée jeudi dernier par le New York Times.
(...) Lisa Cosgrove a identifié les membres des panels puis recherché, dans les publications médicales, quels étaient les auteurs qui avaient fait des déclarations de conflits d'intérêt (les revues savantes réclament de plus en plus cette précaution minimale). Elle a également recherché dans des bases de données d'éventuelles participations à des travaux financés par l'industrie.